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all-trans-Retinoic acid-d<sub>6</sub>

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2808

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2726

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-14649
    Retinoic acid
    Maximum Cited Publications
    50 Publications Verification

    Vitamin A acid; all-trans-Retinoic acid; ATRA

    		 Organoid RAR/RXR PPAR Endogenous Metabolite Autophagy Cancer
    Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
    <em>Retinoic</em> acid
  • HY-14649S4
    Retinoic acid-d5

    Vitamin A acid-d<sub>5sub>; all-trans-Retinoic acid-d<sub>5sub>; ATRA-d<sub>5sub>

    		 Isotope-Labeled Compounds RAR/RXR PPAR Cancer
    Retinoic acid-d5 is the the deuterium labeled Retinoic acid (HY-14649). Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha .
    <em>Retinoic</em> acid-d5
  • HY-14649R
    Retinoic acid (Standard)
    Maximum Cited Publications
    50 Publications Verification

    Vitamin A acid (Standard); all-trans-Retinoic acid (Standard); ATRA (Standard)

    		 RAR/RXR PPAR Endogenous Metabolite Autophagy Cancer
    Retinoic acid (Standard) is the analytical standard of Retinoic acid. This product is intended for research and analytical applications. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha.
    <em>Retinoic</em> acid (Standard)
  • HY-14649S3
    Retinoic acid-d6

    Vitamin A acid-d<sub>6sub>; all-trans-Retinoic acid-d<sub>6sub>; ATRA-d<sub>6sub>

    		 RAR/RXR PPAR Autophagy Endogenous Metabolite Cancer
    Retinoic acid-d6 is the deuterium labeled Retinoic acid[1]. Retinoic acid is a metabolite of vitamin A that plays important roles in cell growth, differentiation, and organogenesis. Retinoic acid is a natural agonist of RAR nuclear receptors, with IC50s of 14 nM for RARα/β/γ. Retinoic acid bind to PPARβ/δ with Kd of 17 nM. Retinoic acid acts as an inhibitor of transcription factor Nrf2 through activation of retinoic acid receptor alpha[2][3][4][5][6][7].
    <em>Retinoic</em> acid-d<em>6</em>
  • HY-14649G
    Retinoic acid

    Vitamin A acid; all-trans-Retinoic acid; ATRA

    		 RAR/RXR Cancer
    Retinoic acid (Vitamin A acid) (GMP) is Retinoic acid (HY-14649) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. Retinoic acid is an agonist of RAR nuclear receptors [6].
    Retinoic acid
  • HY-RS13999
    SUB1 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SUB1 Human Pre-designed siRNA Set A contains three designed siRNAs for SUB1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SUB1 Human Pre-designed siRNA Set A
    SUB1 Human Pre-designed siRNA Set A
  • HY-146227
    DNA topoisomerase II inhibitor 1

    		Topoisomerase Apoptosis Cancer
    DNA topoisomerase II inhibitor 1 (compound 8ed) is a potent DNA topoisomerase II inhibitor. DNA topoisomerase II inhibitor 1 shows anti-proliferative activity. DNA topoisomerase II inhibitor 1 induces apoptosis and cell cycle arrest at sub G1 phase .
    DNA topoisomerase II inhibitor 1
  • HY-100560S
    Abscisic acid-d6

    (S)​-​(+)​-​Abscisic acid-d<sub>6sub>; ABA-d<sub>6sub>

    		 Proton Pump Metabolic Disease
    Abscisic acid-d6 is deuterium labeled Abscisic acid. Abscisic acid inhibits proton pump (H+-ATPase)[1].
    Abscisic acid-d<em>6</em>
  • HY-N0593S2
    Deoxycholic acid-d6

    Cholanoic acid-d<sub>6sub>; Desoxycholic acid-d<sub>6sub>

    		 Isotope-Labeled Compounds G protein-coupled Bile Acid Receptor 1 Endogenous Metabolite Metabolic Disease
    Deoxycholic acid-d6 is the deuterium labeled Deoxycholic acid. Deoxycholic acid is specifically responsible for activating the G protein-coupled bile acid receptor TGR5 that stimulates brown adipose tissue (BAT) thermogenic activity.
    Deoxycholic acid-d<em>6</em>
  • HY-B0236S
    6-Aminocaproic acid-d6

    EACA-d<sub>6sub>; Epsilon-Amino-n-caproic acid-d<sub>6sub>; 6-Aminohexanoic acid-d<sub>6sub>

    		 Isotope-Labeled Compounds Metabolic Disease
    6-Aminocaproic acid-d6 is deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].
    <em>6</em>-Aminocaproic acid-d<em>6</em>
  • HY-B1350S
    Fusidic acid-d6

    Fusidate-d<sub>6sub>; SQ-16603-d<sub>6sub>

    		 Bacterial Antibiotic Infection
    Fusidic acid-d6 is the deuterium labeled Fusidic acid. Fusidic acid (Fusidate) a bacteriostatic antibiotic produced from the Fusidium coccineum fungus, belongs to the class of steroids. Fusidic acid has no corticosteroid effects. Fusidic acid inhibits the growth of bacteria by preventing the release of translation elongation factor G (EF-G) from the ribosome[1][2].
    Fusidic acid-d<em>6</em>
  • HY-N0610AS
    Cinnamic acid-d6

    3-Phenylacrylic acid-d<sub>6sub>; β-Phenylacrylic acid-d<sub>6sub>

    		 Endogenous Metabolite Cancer
    Cinnamic acid-d6 is the deuterium labeled Cinnamic acid. Cinnamic acid has potential use in cancer intervention, with IC50s of 1-4.5 mM in glioblastoma, melanoma, prostate and lung carcinoma cells.
    Cinnamic acid-d<em>6</em>
  • HY-12222S
    Obeticholic acid-d5

    INT-747-d<sub>5sub>; 6-ECDCA-d<sub>5sub>; 6-Ethylchenodeoxycholic acid-d<sub>5sub>

    		 FXR Autophagy Others
    Obeticholic acid-d5 is the deuterium labeled Obeticholic acid. Obeticholic acid (INT-747) is a potent, selective and orally active FXR agonist with an EC50 of 99 nM. Obeticholic acid has anticholeretic and anti-inflammation effect. Obeticholic acid also induces autophagy[1][2][3].
    Obeticholic acid-d5
  • HY-10585S1
    Valproic acid-d6

    VPA-d<sub>6sub>; 2-Propylpentanoic acid-d<sub>6sub>

    		 HDAC Autophagy Mitophagy HIV Notch Endogenous Metabolite Cancer
    Valproic acid-d6 is the deuterium labeled Valproic acid. Valproic acid (VPA; 2-Propylpentanoic Acid) is an HDAC inhibitor, with IC50 in the range of 0.5 and 2 mM, also inhibits HDAC1 (IC50, 400 μM), and induces proteasomal degradation of HDAC2. Valproic acid activates Notch1 signaling and inhibits proliferation in small cell lung cancer (SCLC) cells. Valproic acid sodium salt is used in the treatment of epilepsy, bipolar disorder and prevention of migraine headaches[1][2].
    Valproic acid-d<em>6</em>
  • HY-14531
    Talarozole
    15+ Cited Publications

    R115866

    		 RAR/RXR Cytochrome P450 Autophagy Inflammation/Immunology
    Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM, respectively.
    Talarozole
  • HY-N0420S
    Succinic acid-d6

    Wormwood acid-d<sub>6sub>

    		 Endogenous Metabolite Metabolic Disease
    Succinic acid-d6 is the deuterium labeled Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle, as well as one of fermentation products of anaerobic metabolism.
    Succinic acid-d<em>6</em>
  • HY-101108S
    Tazarotenic acid-d6

    AGN 190299-d<sub>6sub>

    		 Isotope-Labeled Compounds Drug Metabolite Others
    Tazarotenic acid-d6 is deuterium labeled Tazarotenic acid. Tazarotenic acid is the metabolite of Tazarotene. Tazarotenic acid binding to retinoic acid receptors (RARs) is the probable molecular target of retinoid action. Tazarotenic acid has the potential for the research of warty dyskeratoma .
    Tazarotenic acid-d<em>6</em>
  • HY-B0167S
    Salicylic acid-d6

    2-Hydroxybenzoic acid-d<sub>6sub>

    		 COX Autophagy Mitophagy Apoptosis Inflammation/Immunology Cancer
    Salicylic acid-d6 is a deuterium labeled Salicylic acid. Salicylic acid inhibits cyclo-oxygenase-2 (COX-2) activity independently of transcription factor (NF-κB) activation[1].
    Salicylic acid-d<em>6</em>
  • HY-B0236S1
    6-Aminocaproic acid-d10

    EACA-d<sub>10sub>; Epsilon-Amino-n-caproic acid-d<sub>10sub>; 6-Aminohexanoic acid-d<sub>10sub>

    		 Isotope-Labeled Compounds Metabolic Disease
    6-Aminocaproic acid-d10 is the deuterium labeled 6-Aminocaproic acid. 6-Aminocaproic acid (EACA), a monoamino carboxylic acid, is a potent and orally active inhibitor of plasmin and plasminogen. 6-Aminocaproic acid is a potent antifibrinolytic agent. 6-Aminocaproic acid prevents clot lysis through the competitive binding of lysine residues on plasminogen, inhibiting plasmin formation and reducing fibrinolysis. 6-Aminocaproic acid can be used for the research of bleeding disorders[1][2].
    <em>6</em>-Aminocaproic acid-d10
  • HY-70002BS
    Enzalutamide carboxylic acid-d6

    MDV3100 carboxylic acid-d<sub>6sub>

    		 Autophagy Androgen Receptor Isotope-Labeled Compounds Cancer
    Enzalutamide carboxylic acid-d6 is the deuterium labeled Enzalutamide carboxylic acid (MDV3100 carboxylic acid). Enzalutamide carboxylic acid is an inactive metabolite of Enzalutamide[1].
    Enzalutamide carboxylic acid-d<em>6</em>
  • HY-A0143S
    Dihomo-γ-linolenic acid-d6

    DGLA-d<sub>6sub>; all-cis-8,11,14-Eicosatrienoic acid-d<sub>6sub>

    		 Endogenous Metabolite Cardiovascular Disease Inflammation/Immunology Cancer
    Dihomo-γ-linolenic acid-d6 (DGLA-d6) is the deuterium labeled Dihomo-γ-linolenic acid. Dihomo-γ-linolenic acid (all-cis-8,11,14-Eicosatrienoic acid) is a 20-carbon ω-6 fatty acid, with anti-inflammatory and anti-proliferative activities. Dihomo-γ-linolenic acid attenuates atherosclerosis in the apolipoprotein E deficient mouse model system[1][2][3].
    Dihomo-γ-linolenic acid-d<em>6</em>
  • HY-14802
    Talarozole (R enantiomer)

    (R)-Talarozole

    		 Cytochrome P450 Cancer
    Talarozole R enantiomer is a potent and selective inhibitor of cytochrome P450 26-mediated breakdown of endogenous all-trans retinoic acid for the treatment of psoriasis and acne.
    Talarozole (R enantiomer)
  • HY-12771S2
    O-Desmethyl Mebeverine acid-d6

    Mebeverine metabolite O-desmethyl Mebeverine acid-d<sub>6sub>

    		 Isotope-Labeled Compounds Drug Metabolite Neurological Disease
    O-Desmethyl Mebeverine acid-d6 is deuterium labeled O-desmethyl Mebeverine acid.
    O-Desmethyl Mebeverine acid-d<em>6</em>
  • HY-108398AS
    Mead acid-d6

    5,8,11-Eicosatrienoic acid-d<sub>6sub>

    		 Isotope-Labeled Compounds Metabolic Disease Cancer
    Mead acid-d6 is the deuterium labeled Mead acid. Mead acid (5,8,11-Eicosatrienoic acid), an unsaturated (Omega-9) fatty acid, is an indicator of essential fatty acid deficiency[1].
    Mead acid-d<em>6</em>
  • HY-N0351S1
    p-Coumaric acid-d6

    trans-4-Hydroxycinnamic acid-d<sub>6sub>

    		 Endogenous Metabolite Cancer
    p-Coumaric acid-d6 is the deuterium labeled p-Coumaric acid (HY-N0351). p-Coumaric acid is the abundant isomer of cinnamic acid which has antitumor and anti-mutagenic activities[1][2].
    p-Coumaric acid-d<em>6</em>
  • HY-B0715S
    Pentoxifylline-d6

    BL-191-d<sub>6sub>; PTX-d<sub>6sub>; Oxpentifylline-d<sub>6sub>

    		 Phosphodiesterase (PDE) Autophagy HIV Cardiovascular Disease Cancer
    Pentoxifylline-d6 is the deuterium labeled Pentoxifylline. Pentoxifylline (BL-191), a haemorheological agent, is an orally active non-selective phosphodiesterase (PDE) inhibitor, with immune modulation, anti-inflammatory, hemorheological, anti-fibrinolytic and anti-proliferation effects. Pentoxifylline can be used for the research of peripheral vascular disease, cerebrovascular disease and a number of other conditions involving a defective regional microcirculation[1][2][3].
    Pentoxifylline-d<em>6</em>
  • HY-15494S1
    Picropodophyllin-d6

    AXL1717-d<sub>6sub>; Picropodophyllotoxin-d<sub>6sub>; PPP-d<sub>6sub>

    		 Isotope-Labeled Compounds IGF-1R Apoptosis Endocrinology Cancer
    Picropodophyllin-d6 (AXL1717-d6) is deuterium labeled Picropodophyllin. Picropodophyllin (AXL1717) is a selective insulin-like growth factor-1 receptor (IGF-1R) inhibitor with an IC50 of 1 nM.
    Picropodophyllin-d<em>6</em>
  • HY-B1873S
    Methoxychlor-d6

    DMDT-d<sub>6sub>; Methoxcide-d<sub>6sub>; Methoxy-DDT-d<sub>6sub>

    		 Isotope-Labeled Compounds Others
    Methoxychlor-d6 is the deuterium labeled Methoxychlor[1].
    Methoxychlor-d<em>6</em>
  • HY-W056964S
    Naphthalene-2,6-dicarboxylic acid-d6

    Naphthalene-2,6-dicarboxylate-d<sub>6sub>

    		 Isotope-Labeled Compounds Others
    Naphthalene-2,6-dicarboxylic acid-d6 is the deuterium labeled Naphthalene-2,6-dicarboxylic acid[1].
    Naphthalene-2,<em>6</em>-dicarboxylic acid-d<em>6</em>
  • HY-76542S
    Vitamin D2-d6

    Ergocalciferol-d<sub>6sub>; Calciferol-d<sub>6sub>; Ercalciol-d<sub>6sub>

    		 VD/VDR Endogenous Metabolite Metabolic Disease
    Vitamin D2-d6 is the deuterium labeled Vitamin D2. Vitamin D2 (Ergocalciferol), drived from plant sources or dietary supplements, could be used as supplement of Vitamin D[1][2].
    Vitamin D2-d<em>6</em>
  • HY-N0537S9
    Xylose-d6

    D-(+)-Xylose-d<sub>6sub>; (+)-Xylose-d<sub>6sub>; Wood sugar-d<sub>6sub>

    		 Isotope-Labeled Compounds Endogenous Metabolite Others
    Xylose-d6 is the deuterium labeled Xylose.
    Xylose-d<em>6</em>
  • HY-N1214S
    Squalene-d6

    Super Squalene-d<sub>6sub>; trans-Squalene-d<sub>6sub>; AddaVax-d<sub>6sub>

    		 Isotope-Labeled Compounds Others
    Squalene-d6 is a deuterium labeled Squalene. Squalene (Super Squalene) is an intermediate product in the synthesis of cholesterol, and shows several pharmacological properties such as hypolipidemic, hepatoprotective, antiatherosclerotic, cardioprotective, antioxidant, and antitumour activity .
    Squalene-d<em>6</em>
  • HY-119695AS
    Simvastatin acid-d6 ammonium

    Tenivastatin-d<sub>6sub> ammonium

    		 Isotope-Labeled Compounds Endogenous Metabolite Cardiovascular Disease
    Simvastatin acid-d6 (ammonium)mis the deuterium labeled Simvastatin acid ammonium. Simvastatin ammonium is an active metabolite of simvastatin lactone mediated by CYP3A4/5 in the intestinal wall and liver (pKa=5.5). Simvastatin ammonium reduces indoxyl sulfate-mediated reactive oxygen species and modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene[1].
    Simvastatin acid-d<em>6</em> ammonium
  • HY-41681S
    6-Chloro-1-hexanol-d6

    1-Chloro-6-hexanol-d<sub>6sub>; 1-Chloro-6-hydroxyhexane-d<sub>6sub>; 6-Chlorohexanol-d<sub>6sub>

    		 Isotope-Labeled Compounds Others
    6-Chloro-1-hexanol-d6 is the deuterium labeled 6-Chloro-1-hexanol[1].
    <em>6</em>-Chloro-1-hexanol-d<em>6</em>
  • HY-N0067S
    γ-Aminobutyric acid-d6

    4-Aminobutyric acid-d<sub>6sub>

    		 GABA Receptor Endogenous Metabolite Neurological Disease
    γ-Aminobutyric acid-d6 is the deuterium labeled γ-Aminobutyric acid. γ-Aminobutyric acid (4-Aminobutyric acid) is a major inhibitory neurotransmitter in the adult mammalian brain[1][2], binding to the ionotropic GABA receptors (GABAA receptors) and metabotropic receptors (GABAB receptors)[2].
    γ-Aminobutyric acid-d<em>6</em>
  • HY-50896S
    Erlotinib-d6

    CP-358774-d<sub>6sub>; NSC 718781-d<sub>6sub>; OSI-774-d<sub>6sub>

    		 EGFR Cancer
    Erlotinib-d6 (CP-358774 D6) is a deuterium labeled Erlotinib (CP-358774). Erlotinib is a directly acting inhibitor EGFR tyrosine kinase inhibitor with an IC50 of 2 nM for human EGFR[1]. Erlotinib-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Erlotinib-d<em>6</em>
  • HY-N0005S
    Curcumin-d6

    Diferuloylmethane-d<sub>6sub>; Natural Yellow 3-d<sub>6sub>; Turmeric yellow-d<sub>6sub>

    		 Keap1-Nrf2 Ferroptosis Autophagy Histone Acetyltransferase Epigenetic Reader Domain Mitophagy Influenza Virus Infection Metabolic Disease Inflammation/Immunology
    Curcumin-d6is a deuterium labeled Curcumin (Turmeric yellow). Curcumin (Turmeric yellow) is a natural phenolic compound with diverse pharmacologic effects including anti-inflammatory, antioxidant, antiproliferative and antiangiogenic activities. Curcumin is an inhibitor of p300 histone acetylatransferase (HATs) and also shows inhibitory effects on NF-κB and MAPKs.
    Curcumin-d<em>6</em>
  • HY-12176AS
    Aliskiren-d6 hydrochloride

    CGP 60536-d<sub>6sub> Hydrochloride; CGP60536Bd<sub>6sub> Hydrochloride; SPP 100d<sub>6sub>(Hydrochloride)

    		 Isotope-Labeled Compounds Renin Cardiovascular Disease Cancer
    Aliskiren-d6 (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.
    Aliskiren-d<em>6</em> hydrochloride
  • HY-13011S1
    Alectinib-d6

    CH5424802-d<sub>6sub>; RO5424802-d<sub>6sub>; AF802-d<sub>6sub>

    		 Isotope-Labeled Compounds Anaplastic lymphoma kinase (ALK) Cancer
    Alectinib-d6 is deuterium labeled Alectinib. Alectinib (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively[1]. Alectinib demonstrates effective central nervous system (CNS) penetration[2].
    Alectinib-d<em>6</em>
  • HY-100977S
    Dimethoxycurcumin-d6

    DiMC-d<sub>6sub>; CHC 004-d<sub>6sub>; Di-O-methylcurcumin-d<sub>6sub>

    		 Isotope-Labeled Compounds Inflammation/Immunology
    Dimethoxycurcumin-d6 is the deuterium labeled Dimethoxycurcumin (HY-100977). Dimethoxycurcumin is a derivative of Curcumin that has anti-inflammatory and antioxidant activities .
    Dimethoxycurcumin-d<em>6</em>
  • HY-N0113S
    Hordenine-d6

    Ordenina-d<sub>6sub>; Peyocactine-d<sub>6sub>

    		 Isotope-Labeled Compounds Bacterial Antibiotic Infection Cardiovascular Disease
    Hordenine-d6 (Ordenina-d6) is the deuterium labeled Hordenine. Hordenine, an alkaloid found in plants, inhibits melanogenesis by suppression of cyclic adenosine monophosphate (cAMP) production .
    Hordenine-d<em>6</em>
  • HY-N0283S
    Diacerein-d6

    Diacerhein-d<sub>6sub>; Diacetylrhein-d<sub>6sub>

    		 Interleukin Related Inflammation/Immunology
    Diacerein-d6 is the deuterium labeled Diacerein[1]. Diacerein (Diacerhein), a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases[2].
    Diacerein-d<em>6</em>
  • HY-Y0504S4
    Trimethylammonium chloride-d6

    Hegzadesil-d<sub>6sub>; Trimethylamine hydrochloric acid-d<sub>6sub>; Trimethylamine monohydrochloride-d<sub>6sub>

    		 Endogenous Metabolite Metabolic Disease
    Trimethylammonium chloride-d6 is the deuterium labeled Trimethylammonium chloride[1]. Trimethylammonium chloride is an endogenous metabolite.
    Trimethylammonium chloride-d<em>6</em>
  • HY-B0005S1
    Toremifene-d6 hydrochloride

    Z-Toremifene-d<sub>6sub> hydrochloride; NK 622-d<sub>6sub> hydrochloride; FC-1157a-d<sub>6sub> hydrochloride

    		 Isotope-Labeled Compounds Estrogen Receptor/ERR Infection
    Toremifene-d6 (Z-Toremifene-d6) hydrochloride is deuterium labeled Toremifene. Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis. Toremifene also potent inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 of 0.07 µM and 2.6 µM, respectively .
    Toremifene-d<em>6</em> hydrochloride
  • HY-N2007S
    Veratric acid-d6

    3,4-Dimethoxybenzoic acid-d<sub>6sub>

    		 Isotope-Labeled Compounds COX Reactive Oxygen Species Cardiovascular Disease Inflammation/Immunology
    Veratric acid-d6 is deuterium labeled Veratric acid. Veratric acid (3,4-Dimethoxybenzoic acid) is an orally active phenolic compound derived from vegetables and fruits, has antioxidant[1] and anti-inflammatory activities[3]. Veratric acid also acts as a protective agent against hypertension-associated cardiovascular remodelling[2]. Veratric acid reduces upregulated COX-2 expression, and levels of PGE2, IL-6 after UVB irradiation[3].
    Veratric acid-d<em>6</em>
  • HY-15459S
    Cabazitaxel-d6

    XRP6258-d<sub>6sub>; RPR-116258A-d<sub>6sub>; taxoid XRP6258-d<sub>6sub>

    		 Microtubule/Tubulin Autophagy Cancer
    Cabazitaxel-d6 is the deuterium labeled Cabazitaxel. Cabazitaxel is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity[1][2].
    Cabazitaxel-d<em>6</em>
  • HY-B0457S1
    Clomipramine-d6 hydrochloride

    Chlorimipramine-d<sub>6sub> (hydrochloride); G-34586-d<sub>6sub> (hydrochloride); NSC-169865-d<sub>6sub> (hydrochloride)

    		 Serotonin Transporter Neurological Disease
    Clomipramine-d6 (hydrochloride) is the deuterium labeled Clomipramine hydrochloride. Clomipramine (Chlorimipramine) hydrochloride is a potent 5-HT reuptake blocker with the IC50 value of 1.5 nM. Clomipramine hydrochloride is a tricyclic antidepressant that can be used for the research of depression and obsessive compulsive disorder (OCD)[1].
    Clomipramine-d<em>6</em> hydrochloride
  • HY-19489S
    (±)-Levomepromazine-d6

    (±)-Methotrimeprazine-d<sub>6sub>; dl-Methotrimeprazine-d<sub>6sub>

    		 Dopamine Receptor Histamine Receptor Neurological Disease
    (±)-Levomepromazine-d6 is the deuterium labeled Methotrimeprazine, which is a D3 dopamine and Histamine H1 receptor antagonist.
    (±)-Levomepromazine-d<em>6</em>
  • HY-90001S
    Ritonavir-d6

    ABT 538-d<sub>6sub>; RTV-d<sub>6sub>

    		 HIV Protease HIV SARS-CoV Apoptosis Infection
    Ritonavir-d6 is the deuterium labeled Ritonavir. Ritonavir (ABT 538) is an inhibitor of HIV protease used to treat HIV infection and AIDS. Ritonavir is also a SARS-CoV 3CLpro inhibitor with an IC50 of 1.61 μM[1][2].
    Ritonavir-d<em>6</em>
  • HY-15772S
    Osimertinib-d6

    AZD-9291-d<sub>6sub>; Mereletinib-d<sub>6sub>

    		 EGFR Cancer
    Osimertinib-d6 is a deuterium labeled osimertinib. Osimertinib is a covalent, orally active, irreversible, and mutant-selective EGFR inhibitor with an apparent IC50 of 12 nM against L858R and 1 nM against L858R/T790M. Osimertinib overcomes T790M-mediated resistance to EGFR inhibitors in lung cancer[1].
    Osimertinib-d<em>6</em>

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